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Registered Programmes (YLL SoM) Allergy Asthma and Immunology Research Research Theme Immunopathogenesis of asthma and allergies towards advances in diagnostic and immunotherapeutic modalities. Gerontology Research Programme Research Theme Healthy and productive aging. A systematic and coordinated programme of research activities on the health of the elderly population in Singapore, it aims to help the understanding of the population aging transition and provide the scientific information needed for formulating strategies of disease prevention and health promotion. Research Theme To identify molecular mechanisms of pathogenesis of Helicobacter Pylori and improve treatment. Specific Themes · Molecular mechanisms of H. pylori pathogenesis. · The use of probiotic/prebiotics as alternative therapeutic strategy. Human and Molecular Genetics Research Programme Research Theme To establish and develop genetic research and diagnostic facilities in cardiovascular, asthma, endocrine, neurometabolic, haematologyoncology, renal and developmental genetics, with regards to: · Genetic epidemiology, including sequencing, mutation screening, and genotyping. · Establishment of a cord blood bank resource representative of Singapore's three major ethnic groups. · Karyotyping and gene mapping by linkage analysis and molecular cytogenetics. · Molecular diagnostics and gene therapy. · Functional genomics and pharmacogenomics. · Animal models of human development and disease. Lactic Acid Bacteria (LAB) Interest Group Research Theme Intestinal lactic acid bacteria as probiotics and vectors for gene therapy. Research Theme To study factors which contribute to, or modulate, degeneration of the nervous system. Research is centered on the calcium hypothesis of aging and dementia, and examines factors that contribute to, or modulate calcium influx into neurons. The role of calcium dependent and free radicals in events leading to neurodegeneration, and the role of glial cells in propagating neuronal injury are also examined. In addition to calcium, an accumulation of iron and cholesterol oxidation products can also be toxic to neurons, and research is carried out, to elucidate iron and cholesterol metabolism in the brain Research Theme The pharmacology of drugs that may exert neural, psychological and behavioural changes in animals and human. Oxidants and Antioxidants Research Group Research Theme To study the molecular and cellular biology of the action of oxidants and antioxidants and their role in human disease and human nutrition. Singapore Epidemiology of Eye Diseases (SEED) Centre Research Theme The Singapore Epidemiology of Eye Disease (SEED) program serves to initiate, promote and coordinate ophthalmic epidemiologic research in Singapore and in Asia. The program focuses on major eye diseases of unique importance in Asia, such as myopia and angle-closure glaucoma. SEED will focus on epidemiology and biostatistics, and will include research related to clinical, genetic and molecular epidemiology, evidence-based medicine and outcomes research. Specific Aims · To determine the prevalence, incidence, risk factors & public health impact of eye diseases in Singapore and Asia through the conduct of epidemiological studies. · To foster international collaborations with other ophthalmic epidemiology groups in Asia and worldwide. · To provide research expertise & consultation to other research centers and ophthalmic institutions in Singapore and Asia. · To conduct training programs for clinicians & research students interested in ophthalmic epidemiology. To organize workshops, symposia & international meetings on ophthalmic clinical research and epidemiologic methods. Research Theme Repair and regeneration of musculoskeletal tissues. Venom and Toxin Research Programme Research Theme From venoms to drugs, from toxins to therapeutics. |
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-Generating New Knowledge to Improve Patient Care |
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Research Highlights |
